Neurophysiological mechanisms driving cognitive biases and decision-making in trait anxiety
Uncertainty is thought to be central to many psychiatric disorders, most notably anxiety. Only recently a quantitative understanding of the role played by uncertainty in these disorders has started to emerge, particularly in the context of decision-making. One of the key findings is that trait anxiety is associated with impairments in decision-making and learning in unstable environments, due to an abnormal estimation of the task statistical structure. This project will expand these findings by assessing the neural correlates underlying the anxiety-induced biases in processing uncertainty during decision-making. Combining MEG and individual T1-MRI, our goal is to assess whether neural activity in the anterior cingulate cortex and prefrontal areas – known to contribute to the symptoms in anxiety disorders – underlie the impairments in uncertainty processing in anxiety, and thus lead to poorer learning and decision-making.
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